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The Experts

D. Blicq dblicq@rrc.mb.ca    Nov. 2006    (update 01/04/2010) DIRECTORY I BIO I NOTICE BOARD

Canada

CIHR (Canadian Inst. of Health Research) -  http://www.cihr-irsc.gc.ca/e/15255.html

Stem Cell Network -  http://www.stemcellnetwork.ca/index_en.php

Health Canada - http://www.hc-sc.gc.ca/sr-sr/pubs/biotech/proc_assi_hum_e.html

Stem Cells.ca   http://www.stemcells.ca/

US  

National Institute of Health -  http://stemcells.nih.gov/

Harvard Stem Cell Institute - http://www.hsci.harvard.edu/index.jsp

University of California - http://stemcellfacts.ucsf.edu/

Britain

Centre for Stem Cell Research - http://cscb.shef.ac.uk/home.htm

Europe

Stem Cell Research - http://www.eurostemcell.org/

 

Selected References:

There is no shortage of active research programs on stem cells and their associated technologies. A few example references are provided below.

  1. Aboody, K.S., Brown, A., Rainov, N.G., Bower, K.A., Liu, Shaoxiong, Yang, W., Small, J.E., Herrlinger, U., Ourednik, V., Black, P.M., Breakefield, X.O., and Snyder, E.Y. (2000). Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97(23):12846-51.
  2. Arantes-Oliviera N, Apfeld J, Dillin A, Kenyon C. Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 2002; 295: 502-5.
  3. Archer DR, Cuddon PA, Lipsitz D, Duncan LD. Myelination of the canine central nervous system by glial cell transplantation: a model for repair of human myelin disease. Nat Med 1997; 3: 54-9.
  4. Bent, S.A. (2005). "Under the Microscope." The Scientist 19 (13): 22-23.
  5. Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell ALL, Jenkins BG, Wahlstedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 2002; 99: 2344-9.

  6. Bittner, R.E., Schofer, C., Weipoltshammer, K., Ivanova, S., Streubel, B., Hauser, E., Freilinger, M., Hoger, H., Elbe-Burger, A., and Wacthler, F. (1999). Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol (Berl) 199:391-6.

  7. Boman BM, Fields JZ, Bonham-Carter O, Runquist OA. Computer modeling implicates stem cell overproduction in colon cancer initiation. Cancer Res 2001; 61: 8408-11.

  8. Caplan AI. Mesenchymal stem cells and gene therapy. Clin Orthop 2000; 379: S67-70.
  9. Clarke RB (2005) Isolation and characterization of human mammary stem cells. Cell Prolif 38: 375-386
  10. Cui Y, Golob J, Kelleher E, Ye Z, Pardoll D, Cheng L. Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells. Blood 2001; 99: 399-408.
  11. Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nat Med 1997; 3: 350-3.
  12. Galderisi U et al. (2006) Stem cells and brain cancer. Cell Death Differ 13: 5-11
  13. Holden, C. and Vogel, G. 2002. Plasticity: Time for a Reappraisal? Science 296: 2126-2129.
  14. Holding, C. (2004). "Sperm mRNA Found in Eggs." Online. BioMed Central. May 13.
  15. Invitrogen/Nature. (2006). "Insight: Stem Cells." Invitrogen and Nature Publishing. June 29. 1059-102. Invitrogen is the leader in stem cell reagents and protocol development and the review focuses on basic science and therapeutic potential.
  16. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, Thomson JA. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2001; 98: 10716-21.
  17. Kim, J.-H., Auberbach, J.M., Rodriguez-Gomez, J.A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S.-H., Nguyen, J., Sanchez-Pernaute, R., Bankiewicz, K., McKay, R. 2002. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.
  18. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 368-77.
  19. Lanza RP (2004) Handbook of Stem Cells: Adult and Fetal Stem Cells. Burlington: Elsevier Academic Press
  20. Leedham SJ et al. (2005) Intestinal stem cells. J Cell Mol Med 9: 11-24
  21. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AB, Deans R, Marshak DR, Flake AW. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6: 1282-6.
  22. Liu S, Qu Y, Stewart TJ, Howard MJ, Chakrabortty S, Holekamp TF, McDonald JW. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci U S A 2000; 97: 6126-31.
  23. Mayhall EA et al. (2004) The clinical potential of stem cells. Curr Opin Cell Biol 16: 713-720
  24. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Uretsky D, Gottlieb DI, Choi DW. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 1999; 5: 1410-2.
  25. McGuckin, C.P. et al. (2005). "Production of stem cells with embryonic characteristics from human umbilical cord blood." Cell Proliferation 38(4): 245.
  26. Mezey et al. (2003). “Transplanted bone marrow generate new neurons in human brains.” PNAS 100:1364-1369.
  27. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Girard B, Bodine DM, Leri A, Anversa P. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001; 98: 10344-9.
  28. Peterson DA. Stem cells in brain plasticity and repair. Curr Opin Pharm 2002; 2: 34-42.
  29. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
  30. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Girard B, Kajstura J, Leri A, Anversa P. Chimerism of the transplanted heart. N Engl J Med 2002; 346: 5-15.
  31. Reya T and Clevers H (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850
  32. Shamblott, M. et al. (1998). "Derivation of pluripotent stem cells from cultured human primordial germ cells." PNAS 95(23): 13726-13731.
  33. Stojkovic, M. et al. (2004). "Derivation, growth and applications of human embryonic stem cells." Reproduction 128(3): 259-267
  34. Studer L, Tabar V, McKay RD. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat Neurosci 1998; 1: 290-5.
  35. Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmoi S, Dunnett SB. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol 1997; 148: 135-46.
  36. United Nations. (2005). "Ad Hoc Committee on an International Convention against the Reproductive Cloning of Human Beings." Online. United Nations. May 18, 2005.
  37. Wertz, D. (2002). "Embryo and stem cell research in the United States: History and politics." Gene Therapy 9(11): 674-678.
  38. Zang, S.C., Wernig, M., Duncan, I.D., Brustle, O., and Thomson, J.A. 2001. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol, 19, 1129-1133.

Retracted Research Papers:

  1. Hwang, W.S. et al. (2005). "Patient-specific embryonic stem cells derived from human SCNT blastocysts." Science 308(5729): 1777-1783. Retracted in 2006.
  2. Hwang, W.S. et al. (2004). "Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst." Science 303(5664): 1669-1674. Retracted in 2006.

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